REGIOSPECIFICITY OF METHYLTHIOMETHYLATION OF NUCLEIC BASES OF THE URACIL SERIES IN THE SYNTHESIS OF NUCLEOSIDES BY THE SILYL METHOD

Authors
ZAVGORODNII SG MALYSHEV AA KONSTANTINOVA ID KUZNETSOV SA MIROSHNIKOV AI
Citation
Sg. Zavgorodnii et al., REGIOSPECIFICITY OF METHYLTHIOMETHYLATION OF NUCLEIC BASES OF THE URACIL SERIES IN THE SYNTHESIS OF NUCLEOSIDES BY THE SILYL METHOD, Bioorganiceskaa himia, 23(7), 1997, pp. 597-599
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
23
Issue
7
Year of publication
1997
Pages
597 - 599
Database
ISI
SICI code
0132-3423(1997)23:7<597:ROMONB>2.0.ZU;2-2
Abstract
It was shown that methylthiomethylation of uracil and its 5-methyl, 5- fluoro, and 6-methyl derivatives by methylthiomethyl chloride or methy lthiomethyl acetate under conditions of the silyl method of nucleoside synthesis in the presence of trimethylsilyl triflate preferentially y ields N1-derivatives. The use of SnCl4 as a catalyst leads to mixtures of N1- and N3-isomers.