CONCOMITANT IV AND ORAL CLODRONATE IN THE RELIEF OF BONE PAIN - A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY IN PATIENTS WITH PROSTATE-CANCER

Authors
KYLMALA T TAUBE T TAMMELA TLJ RISTELI L RISTELI J ELOMAA I
Citation
T. Kylmala et al., CONCOMITANT IV AND ORAL CLODRONATE IN THE RELIEF OF BONE PAIN - A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY IN PATIENTS WITH PROSTATE-CANCER, British Journal of Cancer, 76(7), 1997, pp. 939-942
Citations number
14
Categorie Soggetti
Oncology
Journal title
British Journal of Cancer → ACNP
ISSN journal
00070920
Volume
76
Issue
7
Year of publication
1997
Pages
939 - 942
Database
ISI
SICI code
0007-0920(1997)76:7<939:CIAOCI>2.0.ZU;2-T
Abstract
Fifty-seven patients with advanced prostate cancer resistant to first- line hormonal therapy were treated with estramustine and additionally randomized for treatment with clodronate or placebo. Clodronate treatm ent was started with 5 days intravenous administration (300 mg day(-1) ) and followed by oral treatment (1.6 g day(-1)) for 12 months. Skelet al pain relief was only about 10% better in the clodronate than in the placebo group. The results do not support the superiority of combined intravenous and oral treatment with clodronate compared with oral adm inistration only.