PROLONGED SURVIVAL OF RAT SKIN ALLOGRAFT BY TREATMENT WITH FK506 OINTMENT

Citation
T. Fujita et al., PROLONGED SURVIVAL OF RAT SKIN ALLOGRAFT BY TREATMENT WITH FK506 OINTMENT, Transplantation, 64(6), 1997, pp. 922-925
Citations number
10
Categorie Soggetti
Immunology,Surgery,Transplantation
Journal title
ISSN journal
00411337
Volume
64
Issue
6
Year of publication
1997
Pages
922 - 925
Database
ISI
SICI code
0041-1337(1997)64:6<922:PSORSA>2.0.ZU;2-V
Abstract
Background. We studied the effect of FK506 ointment on rat skin allogr aft survival. Methods. Lewis rat (RT1(1)) skin allografts were histolo gically evaluated on day 9 after transplantation to recipient ACI (RT1 (a)) rats. We set histological gradings for rejection as follows: grad e 1, intraepidermal blister forrmation; grade 2, incomplete epidermal separation from the dermis; and grade 3, complete epidermal separation from the epidermis, According to these histological criteria, the imm unosuppressive effect of FK506 ointment was assessed. Results. Our dat a indicated that all recipient rats without FK506 ointment showed grad e 3 rejection on day 7 after transplantation. In contrast, the allogra fts treated with FK506 ointment showed grade 1 rejection. Furthermore the blood concentration of FK506 was below 0.5 ng/ml, minimizing the s ystemically adverse effects of FK506. Conclusions. Thus, the present s tudy suggests that the topical administration of FK506 on the skin all ografts may be useful and effective in the suppression of skin allogra ft rejection.