T-cell mediated immunity is an important defense mechanism against ame
biasis. However, organ transplant recipients with severe T cell immuno
suppression are not at increased risk of having Entamoeba histolytica
invasive disease, The reasons are unclear and probably multifactorial,
but it is likely that the absence of intestinal colonization with pat
hogenic strains in countries where transplants occur and the judicious
intake of possible contaminated food and water are important contribu
ting factors, We describe the first report of a liver transplant recip
ient with severe E histolytica colitis who was successfully treated wi
th metronidazole without modifying his immunosuppression therapy.