LOCAL ANTIMICROBIAL THERAPY OF ORAL MUCOSITIS IN PEDIATRIC-PATIENTS UNDERGOING BONE-MARROW TRANSPLANTATION

Authors
BONDI E BARONI C PRETE A GATTI M CARRASSI A LODI G PORTER SR
Citation
E. Bondi et al., LOCAL ANTIMICROBIAL THERAPY OF ORAL MUCOSITIS IN PEDIATRIC-PATIENTS UNDERGOING BONE-MARROW TRANSPLANTATION, Oral Oncology, 33(5), 1997, pp. 322-326
Citations number
70
Categorie Soggetti
Oncology,"Dentistry,Oral Surgery & Medicine
Journal title
Oral Oncology → ACNP
ISSN journal
13688375
Volume
33
Issue
5
Year of publication
1997
Pages
322 - 326
Database
ISI
SICI code
1368-8375(1997)33:5<322:LATOOM>2.0.ZU;2-U
Abstract
The present investigation has examined the clinical benefits of tobram ycin, polymyxin E and amphotericin therapy in the management of oral m ucositis in children undergoing chemotherapy prior to bone marrow tran splantation. Tobramycin, polymyxin E, and amphotericin reduced the deg ree of oral mucositis more than conventional therapy of diphenhydramin e, Maalox, and local analgesic. While there was a statistically signif icant fall in the severity of the mucositis with tobramycin, polymyxin E and amphotericin, this was unlikely to be of practical benefit. (C) 1997 Elsevier Science Ltd.