ASSESSMENT OF EPIDERMAL GROWTH-FACTOR IN ORAL SECRETIONS OF PATIENTS RECEIVING RADIATION-THERAPY FOR CANCER

Authors
EPSTEIN JB EMERTON S GUGLIETTA A LE N
Citation
Jb. Epstein et al., ASSESSMENT OF EPIDERMAL GROWTH-FACTOR IN ORAL SECRETIONS OF PATIENTS RECEIVING RADIATION-THERAPY FOR CANCER, Oral Oncology, 33(5), 1997, pp. 359-363
Citations number
14
Categorie Soggetti
Oncology,"Dentistry,Oral Surgery & Medicine
Journal title
Oral Oncology → ACNP
ISSN journal
13688375
Volume
33
Issue
5
Year of publication
1997
Pages
359 - 363
Database
ISI
SICI code
1368-8375(1997)33:5<359:AOEGIO>2.0.ZU;2-M
Abstract
Biological response modifiers have been studied in animal models of or al mucositis. We assessed the presence of epidermal growth factor (EGF ) in patients during radiation therapy for head and neck cancer. The f indings of this preliminary study showed that it is possible to measur e the presence of EGF in oral secretions during radiation therapy. EGF was shown to decrease during the course of radiation therapy, and a t rend was seen with decreasing EGF and increasing oral ulceration (P = 0.10) and increasing total mucositis score (P = 0.09). (C) 1997 Elsevi er Science Ltd.