N-MYRISTOYLATION OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN-KINASE IN THE FREE-LIVING NEMATODE CAENORHABDITIS-ELEGANS

N-Myristoylation of the catalytic subunit (C-subunit) of cAMP-dependen t protein kinase is widespread in animal cells. Some invertebrates exp ress non-myristoylated isoforms of C-subunit but these co-exist with a t least one myristoylated isoform. The generality of this observation implies an indispensable function for myristoylated C-subunit, but not withstanding this, neither of the C-subunit isoforms hitherto describe d in C. elegans is apparently N-myristoylated. In light of this anomal y, the myristoylation status of the C-subunit has been examined in adu lt C. elegans. Evidence is presented for the presence of an N-myristoy lated isoform. (C) 1997 Academic Press.