MICROBIAL REDUCTION OF YL-3-OXOHEXYL)-2,4,4-TRIMETHYLCYCLOPENTA-1,3-DIONE WITH SCHIZOSACCHAROMYCES-POMBE (NRRL Y-164)

Authors
LEE SS YAN JL WANG KC
Citation
Ss. Lee et al., MICROBIAL REDUCTION OF YL-3-OXOHEXYL)-2,4,4-TRIMETHYLCYCLOPENTA-1,3-DIONE WITH SCHIZOSACCHAROMYCES-POMBE (NRRL Y-164), Tetrahedron : asymmetry, 8(18), 1997, pp. 3051-3058
Citations number
5
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
18
Year of publication
1997
Pages
3051 - 3058
Database
ISI
SICI code
0957-4166(1997)8:18<3051:MROY>2.0.ZU;2-3
Abstract
Racemic yl-3-oxohexyl)-2,4,4-trimethylcyclopenta-1,3-dione 4 was resol ved by reduction with Schizosaccharomyces pombe (NRRL Y-164) to give ( -)-5, (+)-6, and (+)-7 in 37, 12, and 19% yields, respectively. Chromi c acid oxidation of (-)-5 gave (+)-4 while oxidation of (+)-6 and (+)- 7 gave (-)-4, respectively. Sodium borohydride reduction of (+)-4 foll owed by Oppenauer oxidation yielded (-)-5 and (-)-7, and the same trea tment of (-)-4 yielded (+)-5 and (+)-7, respectively. (C) 1997 Elsevie r Science Ltd.