PREPARATION OF THE STEREOISOMERS OF 2-CYANOCYCLOALKANOLS BY LIPASE-CATALYZED ACYLATION

Authors
FORRO E LUNDELL K FULOP F KANERVA LT
Citation
E. Forro et al., PREPARATION OF THE STEREOISOMERS OF 2-CYANOCYCLOALKANOLS BY LIPASE-CATALYZED ACYLATION, Tetrahedron : asymmetry, 8(18), 1997, pp. 3095-3099
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
18
Year of publication
1997
Pages
3095 - 3099
Database
ISI
SICI code
0957-4166(1997)8:18<3095:POTSO2>2.0.ZU;2-D
Abstract
Enantiopure (1R,2R)-, (1S,2S)-, (1S,2R)- and (IR,2S)-2-cyanocyclopenta nol and -cyclohexanol, isomers were prepared through the Pseudomonas c epacia lipase-catalysed acetylation of the racemic cis and trans compo unds with vinyl acetate in diisopropyl ether. The quasi-irreversible n ature of acylations with 2,2,2-trifluoroethyl esters is evident. (C) 1 997 Elsevier Science Ltd.