The recent West Coast experience with increased methamphetamine use is
showing signs of spreading to other parts of the US. The risk of corr
esponding medical and psychosocial problems has led to a call to actio
n at the highest levels of government. The next few years will likely
witness a substantial increase in treatment research on methamphetamin
e abuse/dependence, with particular emphasis on the development and ap
plication of novel pharmacotherapies. The evaluation of these agents p
resupposes that we understand the clinical syndrome resulting from chr
onic methamphetamine use. To establish a clear picture of the biologic
al and psychological sequellae of methamphetamine use, we compare two
cohorts (500 methamphetamine and 224 cocaine users) treated at the sam
e outpatient clinic over the past nine years, using identical manualiz
ed treatments. The results suggest that while there are important diff
erences in group characteristics and drug effects, the total response
to treatment was quite comparable.