NEW ANTICANDIDOUS 2-ALKYLTHIO-6-AMINOBENZOTHIAZOLES

The synthesis and antimicrobial activity of six new 2-akenyl-6-aminobe nzothiazoles are reported. The new compounds were prepared by alkenyla tion of the potassium salt of 6-amino-2-mercaptobenzothiazole with alk enyl bromides. The structure of the compounds was verified by H-1 NMR spectra. The compounds have shown antibacterial activity against Staph ylococcus aureus and anticandidous activity against Candida albicans. The optimum structure of the studied compounds has been calculated by quantum chemistry AMI method. The theoretical values of lipophilicity were calculated for all alkenyl substituents.