Background and Objective: The aim of the present study was to investig
ate the tissue ablation capacity of various pulsed lasers at the stape
s footplate. Study Design/Materials and Methods: Isolated human stapes
and bovine compact-bone platelets were used to determine the effectiv
e laser parameters and appropriate application technique for achieving
a perforation measuring 500-600 mu m in diameter. Of interest were al
so the shape and quality of the perforations, the reproducibility of t
he perforation effect, and the thermically altered marginal zones occu
rring at the footplate. Three pulsed laser systems were used: excimer,
holmium:YAG (Ho:YAG), and erbium:YSGG (Er:YSGG) lasers. Results: The
tissue-ablating effect of pulsed laser systems permits a precise and c
ontrolled management of the stapes footplate through low and readily r
eproducible ablation rates. The extent of thermic side effects at the
footplate is lower in comparison to the purely thermically acting cw a
nd superpulse laser systems. The Er:YSGG laser exhibits the highest ab
lation rate at the stapes and is thus the most effective laser for per
foration of the stapes footplate. Though somewhat less effective, the
Ho:YAG laser also appears to be suitable for stapedotomy. On the other
hand, we do not consider the applied excimer laser (308 nm) to be par
ticularly appropriate at the stapes because of its low ablation rates.
Conclusion: Thus, the erbium laser could represent an alternative to
the argon, KTP 532, and CO2 lasers, already clinically successful in s
tapes surgery. However, further studies are neccessary to examine the
transmission of thermic energy into the vestibule and the acoustic str
ess to the inner ear during laser stapedotomy, to be able to make a de
finitive statement about the safest and most effective laser system fo
r stapes surgery. (C) 1997 Wiley-Liss, Inc.