A SYNDROME INCLUDING THUMB MALFORMATIONS, MICROCEPHALY, SHORT STATURE, AND HYPOGONADISM

We report on eight patients from seven different families affected wit h a syndrome which includes thumb defects, short stature, microcephaly , and mental retardation. Most of the patients had additional malforma tions, ire particular amenorrhoea and azoospermia in the adults. There were no haematological manifestations and the chromosomes were normal without evidence of breakage even after stimulation. In five of the c ases the probands' mother received hormonal treatment before or at the beginning of her pregnancy or bath. The syndrome may be inherited as an autosomal recessive trait since the patients included both males an d females and their parents were related in most cases. In addition, s upporting this possibility, they all originated from a small village w hich may be considered as an isolate. However, in all cases but one, o nly one person was affected in each family and there was a significant apparent excess of healthy sibs of the probands. These observations m ay be the result of the variability of the syndrome or a more complex type of inheritance.