DISPOSITION OF AMPICILLIN IN HONEYBEES AND HIVES

Disposition profile of ampicillin (ABPC) among honeybees, larvae, hone y and royal jelly in a hive after oral dosing to adult bees was studie d. Four honeybee colonies were administered the single dose of ABPC at the rate of 30 mg/hive by addition to sugar syrup or pollen substitut e (paste) for 1 day intake. nle colonies received ABPC in syrup showed high drug residue levels in honey and it lasted over 14 days beyond t he detection limit of residual analysis. In the hives given ABPC in pa ste, relatively low honey residues were found, however, the distributi ons of the drug in young larvae and jelly which was the food of the la rvae were very low. ABPC was considered to be a promising drug for the control of American foulbrood, an important bacterial disease of hone ybee larvae, because of its high antibacterial activity to the pathoge n, Paenibacillus larvae, and instability of residue in honey as human food. The low distribution in young larvae, the target of the disease, threw a doubt on the efficacy of ABPC for American foulbrood control.