28-DAY REPEATED-DOSE INHALATION EXPOSURE OF RATS TO DIETHYLENE GLYCOLMONOETHYL ETHER

Citation
Cj. Hardy et al., 28-DAY REPEATED-DOSE INHALATION EXPOSURE OF RATS TO DIETHYLENE GLYCOLMONOETHYL ETHER, Fundamental and applied toxicology, 38(2), 1997, pp. 143-147
Citations number
11
Categorie Soggetti
Toxicology
ISSN journal
02720590
Volume
38
Issue
2
Year of publication
1997
Pages
143 - 147
Database
ISI
SICI code
0272-0590(1997)38:2<143:2RIEOR>2.0.ZU;2-6
Abstract
This study was carried out to provide information on the effects of in halation of diethylene glycol monoethyl ether, a substance used in ind ustry which may be accidentally inhaled by man. Sprague-Dawley CD rats were exposed by inhalation to a test atmosphere containing diethylene glycol monoethyl ether in a nose-only exposure system for 6 hr a day, 5 days a week for 28 days. Mean exposure levels were 0.09, 0.27, and 1.1 mg/liter. At the two lowest exposure levels the test substance was present entirely as vapor, but at the highest exposure level the test atmosphere was approximately equally divided by mass into respirable droplets (aerosol) and vapor. A comprehensive battery of toxicological evaluations including food consumption, body weight, clinical signs, hematology, and biochemistry revealed no evidence of a systemic effect of exposure. Histopathological examination showed changes indicative of mild nonspecific irritation in the upper respiratory tract of rats exposed at the two highest exposure levels. These changes consisted of foci of necrosis in the ventral cartilage of the larynx of rats expos ed at 0.27 or 1.1 mg/liter and an increase in eosinophilic inclusions in the olfactory epithelium of the nasal mucosa of rats exposed at 1.1 mg/liter. The no observed adverse effect level for systemic effects w as 1.1 mg/liter and the no observed adverse effect level for signs ind icative of mild nonspecific irritation of the upper respiratory tract was 0.09 mg/liter. (C) 1997 Society of Toxicology.