GUILLAIN-BARRE-SYNDROME - CLINICAL ANALYSIS AND PATHOLOGICAL-STUDY ONSURAL NERVE BIOPSY OF 40 CASES

Objective To make clinical analysis and pathological study on 40-case Gullain-Barre syndrome with sural nerve biopsy. Methods A total of 90 cases of GBS were retrospectively analyzed of which sural nerve biopsi es were performed in 40 cases. The type of GBS was determined accordin g to Asbury and Ropper criteria, and its correlation with pathological findings was studied. Results In the 40 biopsy cases, demyelination w as the predominant pathological change in 38 cases. Mild axonal degene ration was also seen in 13 of the 38 cases. Prominent axonal degenerat ion was seen in only 2 of 13 cases. The increased monocyte infiltratio n and varied capillary permeability were observed in 19 of 25 cases. O nion-bulb like changes were seen in 6 cases. Conclusion We studied the correlation between paresthesia and the pathological findings of sura l nerve biopsy and concluded that sural nerve biopsy is very useful in the diagnosis of CBS and its variant.