DI-N-BUTYLTIN, TRI-N-BUTYLTIN, AND TRIPHENYLTIN STEROIDCARBOXYLATES -SYNTHESIS, NMR CHARACTERIZATION AND IN-VITRO ANTITUMOR-ACTIVITY

A series of tri- and diorganotin steroidcarboxylates were synthesized and characterized by 1D and 2D H-1, C-13, Sn-117 and H-1-C-13 HMQC and HMBC NMR spectroscopy as well as by Sn-119 MAS NMR. The in vitro anti tumour activities of the di-n-butyltin compound 1 against seven human tumour cell lines, MCF-7 and EVSA-T, two breast cancers, WiDr, a colon cancer, IGROV, an ovarian cancer, M19 MEL, a melanoma, A498, a renal cancer, and H226, a non small cell lung cancer lie between those of 5- fluorouracil and doxorubicin. The activities of the triorganotin compo unds 6, 7, 9 and 11 are comparable to those of methotrexate or doxorub icin.