THE MNIOPETALS, NEW INHIBITORS OF REVERSE TRANSCRIPTASES FROM A MNIOPETALUM SPECIES (BASIDIOMYCETES) .1. PRODUCING ORGANISM, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITIES
A. Kuschel et al., THE MNIOPETALS, NEW INHIBITORS OF REVERSE TRANSCRIPTASES FROM A MNIOPETALUM SPECIES (BASIDIOMYCETES) .1. PRODUCING ORGANISM, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITIES, Journal of antibiotics, 47(7), 1994, pp. 733-739
Six novel enzyme inhibitors of RNA-directed DNA-polymerases of human i
mmunodeficiency-, avian myeloblastosis and murine leukemia viruses wer
e isolated from fermentations of a canadian Mniopetalum species. They
were named mniopetals A, B, C, D, E and F. Their structures were eluci
dated by spectroscopic methods. The compounds, in addition to their in
hibitory activities on reverse transcriptases, exhibit antimicrobial a
nd cytotoxic properties.