PNEUMOCANDIN D-0, A NEW ANTIFUNGAL AGENT AND POTENT INHIBITOR OF PNEUMOCYSTIS-CARINII

Authors
MORRIS SA SCHWARTZ RE SESIN DF MASUREKAR P HALLADA TC SCHMATZ DM BARTIZAL K HENSENS OD ZINK DL
Citation
Sa. Morris et al., PNEUMOCANDIN D-0, A NEW ANTIFUNGAL AGENT AND POTENT INHIBITOR OF PNEUMOCYSTIS-CARINII, Journal of antibiotics, 47(7), 1994, pp. 755-764
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
47
Issue
7
Year of publication
1994
Pages
755 - 764
Database
ISI
SICI code
0021-8820(1994)47:7<755:PDANAA>2.0.ZU;2-X
Abstract
Pneumocandin D-0 (9), a new member of the echinocandin class of antifu ngal agents, has been isolated as a minor constituent from fermentatio n broths of the filamentous fungi Zalerion arboricola (ATCC 20957). Th e structure of 9 has been determined mainly on the basis of spectrosco pic analysis and by comparison with published data for similar compoun ds. To date, pneumocandin D-0 has been found to be the most potent inh ibitor of Pneumocystis carinii development in vivo within the natural- occuring echinocandin family of antifungal agents.