ANTIMICROBIAL ACTIVITIES OF INDOLOCARBAZOLE AND BIS-INDOLE PROTEIN-KINASE-C INHIBITORS

The antimicrobial activities of twenty-two substances structurally rel ated to staurosporine, aglycone in the indolocarbazole and bis-indole series were examined against Streptomyces chartreusis and Streptomyces griseus, Bacillus cereus, Escherichia coli, Candida albicans and Botr ytis cinerea. Inhibition of sporulation was examined also on the two s pecies of Streptomyces. Unlike literature reports for efficient protei n kinase inhibitors, staurosporine and K-252a, no evident correlation could be found either between protein kinase inhibitory potencies and inhibition of sporulation of the Streptomyces species, or protein kina se inhibitory potencies and growth of all microorganisms tested. A wea k activity against C. albicans was observed for the chloro-indolocarba zole compounds as already reported for structurally related substances from the cyanobacterium Tolypothrix tjipanasensis.