ISOLATION AND CHARACTERIZATION OF THE MAJOR EQUILIBRIUM PRODUCT OF FK-520

Authors
GAILLIOT FP NATISHAN TK BALLARD JM REAMER RA KUCZYNSKI D MCMANEMIN GJ EGAN RS BUCKLAND BC
Citation
Fp. Gailliot et al., ISOLATION AND CHARACTERIZATION OF THE MAJOR EQUILIBRIUM PRODUCT OF FK-520, Journal of antibiotics, 47(7), 1994, pp. 806-811
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
47
Issue
7
Year of publication
1994
Pages
806 - 811
Database
ISI
SICI code
0021-8820(1994)47:7<806:IACOTM>2.0.ZU;2-2
Abstract
The existence of an isomeric form in equilibrium with the major compon ent of FK-520 in polar solutions has been demonstrated. This minor com ponent has been isolated in high yield and purity by a novel crystalli zation strategy and preparative HPLC. The equilibrium product was char acterized by NMR and MS.