INDOMETHACIN IN THE MANAGEMENT OF ELEVATED INTRACRANIAL-PRESSURE - A REVIEW

Elevated intracranial pressure occurs frequently in patients with seve re head injury, A number of studies in recent years suggest that indom ethacin may be useful in the management of elevated intracranial press ure, Indomethacin acts primarily by reducing cerebral blood flow and d ecreasing cerebral edema following head injury. This review summarizes the basic and clinical studies of the effects of indomethacin on cere bral blood flow, brain edema, and intracranial pressure, The pharmacol ogy of indomethacin, and issues for future investigation in the use of indomethacin in severe head injury, are discussed.