M. Yamada et al., PANENCEPHALOPATHIC TYPE OF CREUTZFELDT-JAKOB-DISEASE ASSOCIATED WITH CADAVERIC DURA-MATER GRAFT, Journal of Neurology, Neurosurgery and Psychiatry, 63(4), 1997, pp. 524-527
A 52 year old man with Creutzfeldt-Jakob disease who received a cadave
ric dura mater graft 99 months before the onset is reported. The prion
protein gene was homozygous for methionine at the polymorphic codon 1
29. Neuropathological examination disclosed a panencephalopathic type
of Creutzfeldt-Jakob disease which was characterised by severe involve
ment of the cerebral white matter and cerebellum, as well as of the ce
rebral cortical and deep grey matter. Thus the panencephalopathic type
of Creutzfeldt-Jakob disease may occur in association with cadaveric
dura mater grafts.