ACTIVITY OF A NEW GLYCOPEPTIDE ANTIBIOTIC (LY333328) AGAINST ENTEROCOCCI AND OTHER RESISTANT GRAM-POSITIVE ORGANISMS

A new semi-synthetic glycopeptide, LY333328, was tested for in-vitro a ctivity against 197 strains of enterococci including strains resistant to other glycopeptides. Activity was also assessed against species wi th intrinsic resistance to glycopeptides. For strains of enterococci t ested the LY333328 MIC(90)s were less than or equal to 0.5 mg/L. Enter ococcus faecalis was less susceptible to LY333328 than other enterococ ci with a maximum MIC of 2.0 mg/L. Glycopeptide-resistant strains of e nterococci were not more resistant to LY333328 than glycopeptide-susce ptible strains but intrinsically resistant species had MICs between 4 and 8 mg/L.