THERAPEUTIC EFFECTS OF OMOCONAZOLE NITRATE ON EXPERIMENTAL TINEA-PEDIS, AN INTRACTABLE DERMATOPHYTOSIS, IN GUINEA-PIGS

The therapeutic efficacy of omoconazole nitrate was investigated in an experimental tinea pedis model produced by topical inoculation with T richophyton mentagrophytes in guineapigs, which is pathologically simi lar to naturally infected tinea pedis in humans. Treatment with omocon azole nitrate cream was started on week 2 postinfection and continued for 3 or 4 weeks. Once-a-day application of 1% omoconazole nitrate to the site of infection exhibited an excellent therapeutic efficacy, and was superior to 1% bifonazole cream in culture result. This result su ggests that omoconazole nitrate has a potential usefulness for the tre atment of tinea pedis in humans.