CONCENTRATIONS OF PROPHYLACTIC CEFTRIAXONE IN ABDOMINAL TISSUES DURING PANCREATIC SURGERY

Ceftriaxone concentrations in abdominal tissues were evaluated after a dministration as antibiotic prophylaxis for pancreatic surgery. Ten pa tients were given ceftriaxone (1 g iv) 30 min before surgery. Ceftriax one concentrations in fatty tissues ranged from 2.5 to 6.2 mu g/g. Cef triaxone concentrations were 6.0 +/- 8.6 mu g/g in pancreatic tissues, 2.1 +/- 2.5 mg/L in pancreatic fluid, 1179 +/- 1271 mg/L in pancreati c bile, and 18 +/- 16 mu g/g in the liver. In fatty tissues, 8-10 pati ents had tissue levels greater than the MIG,, for Staphylococcus aureu s and Escherichia coli and the 10 patients had tissue levels greater t han the MIC90 for Klebsiella pneumoniae and Proteus mirabilis. In othe r tissues, penetration was greater than the MIC90 for potential pathog ens in 50-100% of the patients.