Background. For the past 16 years the combined spinal-epidural (CSE) t
echnique has been extensively researched and developed to the point wh
ere it is now in widespread use. Along with the use of low-dose mixtur
es of local anesthetics and opioids, and the introduction of fine-gaug
e pencil-point needles, CSE is being increasingly recognized as anothe
r important addition to the armamentarium of the anesthesiologist. Met
hod. One hundred and forty-two publications focusing on the CSE techni
que, or on questions concerning CSE-related issues, were reviewed. Out
of 33 double-blind or controlled studies, 23 directly investigated th
e CSE technique. Fifty-four prospective studies and letters made direc
tly relevant points on advantages or problems with CSE. Twenty-one boo
k chapters, reviews and editorials were included, 11 of them concernin
g the use of CSE technique. Results. All CSE techniques which may be u
sed for surgical anesthesia, for analgesia in labor or for postoperati
ve pain management are described. Indications, advantages, disadvantag
es, and the various methods for performing CSE procedures, including s
equential CSE block, are described and reviewed, along with the equipm
ent currently available for their administration. Conclusion. The CSE
technique offers many potential advantages over continuous epidural or
subarachnoid methods alone, including a reduction in drug dosage, the
ability to eliminate motor blockade and to achieve highly selective s
ensory blockade and optimize analgesia. These features hold great prom
ise for minimizing the hazards and side effects of traditional epidura
l and subarachnoid techniques. Controversial fears, risks, and pitfall
s of the CSE technique and of continuous epidural and subarachnoid met
hods are debated and discussed.