Rm. Jones et al., ASSIGNMENT OF THE HUMAN GENE ENCODING EUKARYOTIC INITIATION-FACTOR 4E(EIF4E) TO THE REGION Q21-25 ON CHROMOSOME-4, Somatic cell and molecular genetics, 23(3), 1997, pp. 221-223
We recently cloned genomic sequences containing the promoter region fo
r the messenger RNA cap binding protein (eIF4E). As the rate-limiting
step in translation, eukaryotic initiation factor 4E is important in c
ellular growth control. Using oligonucleotide primers specific for the
promoter region in polymerase chain reactions (PCR), we amplified the
human gene in a chromosome 4-specific human/rodent somatic cell panel
. This panel mapped single copy genomic sequences for eIF4E in the reg
ion 4q21 to 4q25.