ESTABLISHING AN OCCUPATIONAL EXPOSURE LIMIT FOR HEXAVALENT CHROMIUM IN THE EUROPEAN-UNION

Citation
Hj. Cross et al., ESTABLISHING AN OCCUPATIONAL EXPOSURE LIMIT FOR HEXAVALENT CHROMIUM IN THE EUROPEAN-UNION, Regulatory toxicology and pharmacology, 26(1), 1997, pp. 72-76
Citations number
1
Categorie Soggetti
Medicine, Legal","Pharmacology & Pharmacy",Toxicology
ISSN journal
02732300
Volume
26
Issue
1
Year of publication
1997
Part
2
Pages
72 - 76
Database
ISI
SICI code
0273-2300(1997)26:1<72:EAOELF>2.0.ZU;2-H
Abstract
A Criteria Document for hexavalent chromium [Cr(VI)], currently under preparation at the Institute of Occupational Health, University of Bir mingham, is intended for use in setting an occupational exposure limit (GEL) for Cr(VI) in the European Union (EU). The requirement for esta blishing OELs, specifically known as indicative limit values, in the E U is set out in Council Directive 80/1107/EEC, amended by Council Dire ctive 88/642/EEC, To facilitate this procedure the Commission has set up a Scientific Committee for Occupational Exposure Limits to Chemical Agents, The Committee, which is composed of independent scientific ex perts from member states, is responsible for reviewing available scien tific data. A Criteria Document forms the basis of the scientific data considered during this process and contains an up-to-date, critical e valuation of available information which is relevant to setting an exp osure limit. After consideration of the scientific data for a particul ar substance, the Committee advises the Commission on setting a health -based GEL, Consideration of other questions such as technical matters and socioeconomic issues occurs during later stages of the procedure, before an OEL is finally adopted, The procedure allows for consultati on with interested parties. The Criteria Document for Cr(VI) contains sections on substance identification, chemical and physical properties , production and use data, recent data on occupational exposure, curre nt methods for measurement and analysis, and toxicology, The toxicolog y section contains a critical evaluation of both human and animal data and forms a major part of the document, This section enables identifi cation of critical health effects associated with exposure to Cr(VI) a nd consideration of dose-response relationships and provides the basis for any risk assessment and recommendation for an GEL. (C) 1997 Acade mic Press.