FAILURE TO CONFIRM ESTROGENIC ACTIVITY FOR BENZOIC-ACID AND CLOFIBRATE - IMPLICATIONS FOR LISTS OF ENDOCRINE-DISRUPTING AGENTS

Authors
ASHBY J LEFEVRE PA ODUM J TINWELL H KENNEDY SJ BERESFORD N SUMPTER JP
Citation
J. Ashby et al., FAILURE TO CONFIRM ESTROGENIC ACTIVITY FOR BENZOIC-ACID AND CLOFIBRATE - IMPLICATIONS FOR LISTS OF ENDOCRINE-DISRUPTING AGENTS, Regulatory toxicology and pharmacology, 26(1), 1997, pp. 96-101
Citations number
11
Categorie Soggetti
Medicine, Legal","Pharmacology & Pharmacy",Toxicology
Journal title
Regulatory toxicology and pharmacology → ACNP
ISSN journal
02732300
Volume
26
Issue
1
Year of publication
1997
Part
1
Pages
96 - 101
Database
ISI
SICI code
0273-2300(1997)26:1<96:FTCEAF>2.0.ZU;2-9
Abstract
Earlier reports that benzoic: acid is uterotrophic to the rat and mous e and that clofibrate is uterotrophic to the rat have not been confirm ed. The studies reported here involved the use of a range of test prot ocols and dose levels, including the protocols/dose levels used by the original investigators. In addition, both chemicals were inactive in a human estrogen receptor (hER(alpha)) yeast estrogenicity assay. It i s concluded that benzoic acid and clofibrate are not estrogenic in the assays used here. This conclusion has implications for the compilatio n of lists of endocrine-disrupting chemicals. (C) 1997 Academic Press.