ANTIINFLAMMATORY ACTIVITY OF ARYLCARBOXYLATOCOPPER(II) COMPLEXES

Using rat paw carrageenan edema, the antiedematous activity of seven s elected arylcarboxylatocopper(II) complexes was assayed and compared t o that of the free acids. m-Cresotato-(mean edema reduction 70%) and p -cresotatocopper(II) (80%) aquacomplexes were more effective than copp er(II) salicylate tetrahydrate (55%) and salicylic acid (42%), used as standards of comparison. The nonsubstituted hydroxyl of salicylate sk eleton of acidoligands is required for the activity of complexes teste d.