ANTIPHLOGISTIC ACTIVITY OF (PHENAZONE) (CRESOXYACETATO)COPPER(II) COMPLEXES

Authors
BLAHOVA M SOKOLIK J TUMOVA I OROSOVA I SVEC P
Citation
M. Blahova et al., ANTIPHLOGISTIC ACTIVITY OF (PHENAZONE) (CRESOXYACETATO)COPPER(II) COMPLEXES, Chemicke listy, 91(9), 1997, pp. 643-644
Citations number
4
Categorie Soggetti
Chemistry
Journal title
Chemicke listy → ACNP
ISSN journal
00092770
Volume
91
Issue
9
Year of publication
1997
Pages
643 - 644
Database
ISI
SICI code
0009-2770(1997)91:9<643:AAO((C>2.0.ZU;2-E
Abstract
Binuclear copper(II) complexes with phenazone (phz) having a general f ormula [Cu-2(ROCH2COO)(4)(phz)(2)] (R = o-, m- and p-methylphenyl) wer e assayed in carrageenan rat paw edema. Their activities (mean edema r eduction 73-87%) were higher than those of the aquacomplexes (43-71%) and copper(II) salicylate tetrahydrate (58%). The highest effect among phenazone complexes exhibited o-cresoxy-acetate derivative.