UREA DERIVATIVES AS TRANSDERMAL PENETRATION ENHANCERS

Authors
HRABALEK A DOLEZAL P KREBS A FARSA O SKLUBALOVA Z
Citation
A. Hrabalek et al., UREA DERIVATIVES AS TRANSDERMAL PENETRATION ENHANCERS, Chemicke listy, 91(9), 1997, pp. 682-683
Citations number
7
Categorie Soggetti
Chemistry
Journal title
Chemicke listy → ACNP
ISSN journal
00092770
Volume
91
Issue
9
Year of publication
1997
Pages
682 - 683
Database
ISI
SICI code
0009-2770(1997)91:9<682:UDATPE>2.0.ZU;2-E
Abstract
The monosubstituted urea derivatives were synthesized as percutaneous penetration enhancers. All compounds prepared were tested in vitro usi ng excised human skin on their enhancing activity for theophyline. The dodecyloxycarbonylpentylurea was found the most effective enhancer wi thin the group of the compounds synthetized with the use of propylene glycol as donor vehicle.