TRANSJUGULAR INTRAHEPATIC PORTOSYSTEMIC SHUNT - A LIMITED ROLE IN REFRACTORY ASCITES

Objective: To evaluate the role of the transjugular intrahepatic porto systemic shunt (TIPS) in the management of patients with refractory as cites. Design: A retrospective study of 25 consecutive patients for wh om refractory ascites was the primary indication for TIPS insertion. S etting: Regional liver unit at Freeman Hospital, Newcastle upon Tyne, UK. Participants and interventions: Twelve male and 13 female patients with a mean age of 58 years and mean Child-Pugh score of 10, treated with TIPS for refractory ascites between July 1992 and September 1995. Main outcome measures: Effect of TIPS on mortality, ascites and hospi tal admission rate. Results: TIPS was successfully placed in all patie nts with a 59% mean reduction in portosystemic pressure gradient. Resp onse rate was 68%, 48% and 33% at 1, 3 and 12 months, respectively. Mo rtality was 48% at 3 months and 67% at 12 months, being higher in thos e patients older than 60, those with renal impairment and those with h igher Child-Pugh score. Amongst nine patients surviving long term (> 1 2 months) the mean time spent in hospital in the 3 months before TIPS was 35 days and in the year following TIPS 30 days. Patients who died (16 in total) spent a mean of 19 days in hospital before TIPS, 10 neve r leaving hospital, and 6 who were discharged spent a mean of 19 days post procedure in hospital (mean survival 84 days). Conclusion: TIPS h as a limited role in the management of patients with refractory ascite s. It is not an appropriate treatment where patients are older than 60 , have renal impairment (creatinine > 200 mu mol/l) or have a Child-Pu gh score greater than 10.