ASYMMETRIC FRIEDEL-CRAFTS REACTION MEDIATED BY NEW CHIRAL AUXILIARIESDERIVED FROM (1S)-(-)-BETA-PINENE - ENANTIOSELECTIVE SYNTHESIS OF (-)-8-NORETHYL,1'-NORMETHYL ETODOLAC

Authors
COSTA PRR CABRAL LM ALENCAR KG SCHMIDT LL VASCONCELLOS MLAA
Citation
Prr. Costa et al., ASYMMETRIC FRIEDEL-CRAFTS REACTION MEDIATED BY NEW CHIRAL AUXILIARIESDERIVED FROM (1S)-(-)-BETA-PINENE - ENANTIOSELECTIVE SYNTHESIS OF (-)-8-NORETHYL,1'-NORMETHYL ETODOLAC, Tetrahedron letters, 38(40), 1997, pp. 7021-7024
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
40
Year of publication
1997
Pages
7021 - 7024
Database
ISI
SICI code
0040-4039(1997)38:40<7021:AFRMBN>2.0.ZU;2-R
Abstract
(-)-8-Norethyl, 1'-normethyl Etodolac (-)-7 was synthesized in ee up t o 95% from a Friedel-Crafts alkylation reaction between tryptophol 4 a nd the chiral beta-ketobutyrate 5h, followed by hydrolysis. (C) 1997 E lsevier Science Ltd.