AN ALLYLIC ISOPRENOID C-5 NUCLEOPHILE FOR THE SYNTHESIS OF FORSKOLIN

Authors
BEHNKE D HAMM S HENNIG L WELZEL P
Citation
D. Behnke et al., AN ALLYLIC ISOPRENOID C-5 NUCLEOPHILE FOR THE SYNTHESIS OF FORSKOLIN, Tetrahedron letters, 38(40), 1997, pp. 7059-7062
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
40
Year of publication
1997
Pages
7059 - 7062
Database
ISI
SICI code
0040-4039(1997)38:40<7059:AAICNF>2.0.ZU;2-2
Abstract
InCl3-mediated coupling of delta-alkoxy allylic stannane 9b with aldeh ydes has been shown to give the a-coupling products in high yield, pro bably via two S-E' processes. Most specifically, drimenal (rac-1) has been converted into labdane derivative 17 which is considered to be an important intermediate on the way to forskolin. (C) 1997 Published by Elsevier Science Ltd.