ASSEMBLING OF THE 4 INDIVIDUAL HELICES CORRESPONDING TO THE TRANSMEMBRANE SEGMENTS (S4 IN REPEAT I-IV) OF THE SODIUM-CHANNEL

Authors
FUTAKI S AOKI M FUKUDA M KONDO F NIWA M KITAGAWA K NAKAYA Y
Citation
S. Futaki et al., ASSEMBLING OF THE 4 INDIVIDUAL HELICES CORRESPONDING TO THE TRANSMEMBRANE SEGMENTS (S4 IN REPEAT I-IV) OF THE SODIUM-CHANNEL, Tetrahedron letters, 38(40), 1997, pp. 7071-7074
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
40
Year of publication
1997
Pages
7071 - 7074
Database
ISI
SICI code
0040-4039(1997)38:40<7071:AOT4IH>2.0.ZU;2-B
Abstract
A template having four cysteines with selectively detachable protectin g groups was developed, which enables selective introduction of indivi dual helices by chemical ligation between the free sulfhydryl group on the template and the chloroacetyl moiety of the helical peptide. Usin g the template, a protein having ion channel activity with rectificati on was obtained. (C) 1997 Elsevier Science Ltd.