STRUCTURE OF KAITOCEPHALIN, A NOVEL GLUTAMATE-RECEPTOR ANTAGONIST PRODUCED BY EUPENICILLIUM-SHEARII

Authors
SHINYA K KIM JS FURIHATA K HAYAKAWA Y SETO H
Citation
K. Shinya et al., STRUCTURE OF KAITOCEPHALIN, A NOVEL GLUTAMATE-RECEPTOR ANTAGONIST PRODUCED BY EUPENICILLIUM-SHEARII, Tetrahedron letters, 38(40), 1997, pp. 7079-7082
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
40
Year of publication
1997
Pages
7079 - 7082
Database
ISI
SICI code
0040-4039(1997)38:40<7079:SOKANG>2.0.ZU;2-B
Abstract
Kaitocephalin was isolated from Eupenicillium shearii as a glutamate r eceptor antagonist, which protected chick telencephalic neurons as wel l as mt hippocampal neurons from kainate toxicity. It consists of a py rrolidine moiety with tricarboxylic acids and a dichlorohydroxybenzoat e substructure as shown in Figure 1. (C) 1997 Elsevier Science Ltd.