INTRODUCTION OF NEW SALINE SOLUTIONS IN EXPERIMENTAL BURN SHOCK

The efficacy of new saline blood substitutes containing antihypoxants sodium acetate (quintasol) or sodium fumarate (mafusol) was studied in experiments on rabbits subjected to a severe burn shock (burn of IIIA -IIIB degree of 18-20% of body surface). The severity of the animals' condition and the efficiency of the solution infusion were judged by t he systemic hemodynamics, oxygen regimen and acid-base status (ABS) of the organism. Four series of the experiments were made: series I (n=2 3) - the burn without treatment; series II (n=16) - infusion of an iso tonic NaCl solution (NaCl). In series III (n=10) animals were given ac etate-containing solution quintasol, in series IV (n=12) - fumarate co ntaining mafusol. Infusion of NaCl did not correct substantially the s ystemic hemodynamics. However, infusion of NaCl inhibited the developm ent of severe hypoxia and decompensated metabolic acidosis observed in untreated animals. infusion of quintasol led to an insignificant impr ovement of circulation. There was a correction and even hypercorrectio n of ABS. Lethality of the animals was the same as in series II. In in fusion of fumarate-containing mafusol cardiac output and stroke volume were higher than in other series. Oxyhemoglobin content and O-2 tensi on in mixed arterio-venous blood reached the initial levels, ABS retur ned to normal. Such a considerable slackening of hypoxia development a fter mafusol infusion seems to be the result of activation of fumarate -dependent oxidation. The survival in this series of the experiments w as the highest. The conclusion is reached that quintasol can be recomm ended for treatment of severe bums in burn shock accompanied by modera te hypoxia to avoid the development of alkalosis. Mafusol, as distinct from quintasol, is indicated in a severe burn shock.