The pathogenicity of a field isolate of western equine encephalitis (W
EE) virus, which was recovered from a breeder hen during investigation
s of egg production drops in California turkey flocks, was tested in 2
-wk-old turkey poults. No symptoms or mortality were observed in poult
s inoculated intramuscularly with 4.2 log(10) 50% embryo lethal doses
of virus; however, the infection did result in mild to moderate lympho
id necrosis in the bursa of Fabricius and thymus glands beginning on t
he first day postinoculation. In addition, WEE virus could be isolated
from the blood of infected poults for up to 3 days postinoculation.