Mediterranean spotted fever is a tick-borne disease that is endemic in
the Mediterranean basin from spring to autumn. Usually mild, the dise
ase can be severe in some cases, especially when risk factors are enco
untered in patients or when treatment is delayed, The correlation betw
een these malignant forms and patients' immunological disorders remain
s unclear, while the pathophysiology of the disease seems well known.
ii case of a malignant form of Mediterranean spotted fever is reported
which occurred 2 months prior to the diagnosis of polymyalgia rheumat
ica. Evidence of immunological disorders consisted only in an antiphos
pholipid antibody associated with a transient lupus anticoagulant. No
underlying risk factors other than the primary undiagnosed phase of po
lymyalgia rheumatica has been observed.