TROLOX-DERIVATIVE ANTIOXIDANT PROTECTS AGAINST METHANOL-INDUCED DAMAGE

This paper reports data on the effect of a new antioxidant, U-83836E, on the lipid peroxidation and antioxidant status of liver, red blood c ells (RBCs) and blood serum of rats intoxicated with methanol (3.0 g/k g body weight). Methanol administration slightly increased the levels of peroxidation products in the liver, and markedly increased them in RBCs and serum. In contrast, glutathione-peroxidase, glutathione-reduc tase activity, reduced glutathione concentration and total antioxidant status were decreased. The use of U-83836E, containing a trolox ring, appeared to be beneficial in reducing lipid peroxidation products and in partially in preventing the decrease in glutathione and antioxidan t enzymes induced by methanol in liver and serum. These results show t hat antioxidant U-83836E may partially prevent methanol toxicity.