BISBENZYLISOQUINOLINE ALKALOIDS FROM STEPHANIA-CEPHARANTHA AND THEIR EFFECTS ON PROLIFERATION OF CULTURED-CELLS FROM THE MURINE HAIR APPARATUS

Authors
NAKAOJI K NAYESHIRO H TANAHASHI T SU Y NAGAKURA N
Citation
K. Nakaoji et al., BISBENZYLISOQUINOLINE ALKALOIDS FROM STEPHANIA-CEPHARANTHA AND THEIR EFFECTS ON PROLIFERATION OF CULTURED-CELLS FROM THE MURINE HAIR APPARATUS, Planta medica, 63(5), 1997, pp. 425-428
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences","Chemistry Medicinal
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
63
Issue
5
Year of publication
1997
Pages
425 - 428
Database
ISI
SICI code
0032-0943(1997)63:5<425:BAFSAT>2.0.ZU;2-T
Abstract
Bisbenzylisoquinoline alkaloids were isolated from Stephania cepharant ha Hayata and their proliferative activities on cultured hair cells fr om the murine skin were evaluated. Cepharanthine (1), cepharanoline (9 ), isotetrandrine (2), and berbamine (7) showed significant activities in the range of 0.01 - 0.1 mu g/ml, but had no activity on cultured k eratinocytes or fibroblasts from the murine skin.