Specific epidemiologic data on myelodysplastic syndromes are rare. Ana
lysis of data is in fact affected by problems of terminology and class
ification. The link between the exposure to ionizing radiation or alky
lating agents and MDS is well established. Etiologic factors of acute
leukemia, or new factors such as non ionizing radiation, solvent, ethy
lene oxide, glycol eters, tobacco smoke, exhaust gases, agricultural w
ork have been hypothesized but should be confirmed by other studies on
MDS.