SYNTHESIS AND CELL-ADHESION PROPERTIES OF CYCLO(-ARG-GLY-ASP-SER-LYS-), A CONSTRAINED ANALOG OF THE ACTIVE DOMAIN OF FIBRONECTIN

Authors
DAVIES JS ENJALBAL C WISE CJ WEBB SE JONES GE
Citation
Js. Davies et al., SYNTHESIS AND CELL-ADHESION PROPERTIES OF CYCLO(-ARG-GLY-ASP-SER-LYS-), A CONSTRAINED ANALOG OF THE ACTIVE DOMAIN OF FIBRONECTIN, Journal of the Chemical Society. Perkin transactions. I, (14), 1994, pp. 2011-2015
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
14
Year of publication
1994
Pages
2011 - 2015
Database
ISI
SICI code
0300-922X(1994):14<2011:SACPOC>2.0.ZU;2-5
Abstract
Details of the synthesis of the protected pentapeptide linear precurso r on a resin with an acid-labile linker, and its subsequent cyclisatio n to cyclo(-Arg-Gly-Asp-Ser-Lys-) are presented. The cyclopentapeptide , which is known to exist in solution in a beta- and gamma-turn confor mation, shows specific differences in its effect on adhesion and cell spreading for fibroblast 3T3 and macrophage Bac 1 cells.