LEUCOVORIN MODULATION OF FLUOROURACIL IN ADVANCED COLORECTAL-CANCER

Authors
DEGRAMONT A LOUVET C ANDRE T TOURNIGAND C RAYMOND E MOLITOR JL KRULIK M
Citation
A. Degramont et al., LEUCOVORIN MODULATION OF FLUOROURACIL IN ADVANCED COLORECTAL-CANCER, La Revue de medecine interne, 18, 1997, pp. 372-378
Citations number
26
Categorie Soggetti
Medicine, General & Internal
Journal title
La Revue de medecine interne → ACNP
ISSN journal
02488663
Volume
18
Year of publication
1997
Supplement
4
Pages
372 - 378
Database
ISI
SICI code
0248-8663(1997)18:<372:LMOFIA>2.0.ZU;2-Y
Abstract
Leucovorin modulation of fluorouracil in advanced colorectal cancer. T he rational of leucovorin modulation of 5-fluorouracil nad the clinica l results in colorectal cancer are reviewed with special emphasis on t he monthly schedule of low dose leucovorin and 5FU bolus for 5 consecu tive days (NCCTG-Mayo Clinic regimen) and the bimonthly schedule of hi gh-dose leucovorin and 5FU bolus plus continous infusion for two conse cutive days (LV5FU2) which is now considered as a new standard.