FIRST STABLE ALPHA-DIOLS AND HEMIKETALS FROM THE ALPHA-HALO PYRUVAMIDE SERIES

Authors
LEMARECHAL AM LEGREL P ROBERT A PAVC J
Citation
Am. Lemarechal et al., FIRST STABLE ALPHA-DIOLS AND HEMIKETALS FROM THE ALPHA-HALO PYRUVAMIDE SERIES, Tetrahedron, 53(40), 1997, pp. 13739-13748
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
40
Year of publication
1997
Pages
13739 - 13748
Database
ISI
SICI code
0040-4020(1997)53:40<13739:FSAAHF>2.0.ZU;2-Z
Abstract
The addition of water or alcohol to 3-halopyruvamides having a special interest in enzymology, permitted us to isolate stable alpha-diols an d hemiketals. until then detected only by spectroscopic means. The rea ction is not diastereoselective. but selective precipitation of only o ne diastereoisomer shifts the equilibrium between the two isomers. Iso lated compounds were Fully characterised and results discussed. (C) 19 97 Elsevier Science Ltd.