SYNTHESIS OF AN ADENINE-PYRIDINALDOXIME-ACRIDINE CONJUGATE FOR RECOGNITION OF ABASIC SITE LESIONS IN DNA

Based on the DNA abasic site targeted artificial enzyme (ATAc 1) previ ously developed in our laboratory, we designed and prepared a new mole cule (2) incorporating a nucleophilic oxime function in the linker. A simple convergent strategy was used for the synthesis. The required py ridinic aldehyde derivative 9 was prepared by selenium oxide oxidation of the corresponding methylpyridine, and the two heteroaromatic moiet ies were successively condensed to afford the conjugate molecule. The oxime function was generated in the last step. (C) 1997 Elsevier Scien ce Ltd.