IMPROVED DISSOLUTION OF OFLOXACIN VIA SOLID DISPERSION

The objective of this study was to improve the dissolution rate of a s paringly water soluble drug, ofloxacin, by solid dispersion systems wi th urea and mannitol. Differential scanning calorimetry (DSC), powder x-ray diffraction (PXRD) analysis and infrared spectroscopy (IR) were performed to evaluate the physicochemical properties of the prepared s olid dispersions. The dissolution rate of ofloxacin was markedly incre ased in solid dispersion of urea and mannitol. Solubility studies reve aled a marked increase in the solubility of ofloxacin with an increase in urea concentration. Mannitol concentration had no effect on the so lubility of ofloxacin. The PXRD study revealed that the crystallinity of ofloxacin was decreased as the ratio of drug to carrier was decreas ed. The results from DSC and IR indicated that there was no interactio n between drug and carriers. (C) 1997 Elsevier Science B.V.