MAMMALIAN ARTIFICIAL CHROMOSOMES - VECTORS FOR SOMATIC GENE-THERAPY

Authors
ASCENZIONI F DONINI P LIPPS HJ
Citation
F. Ascenzioni et al., MAMMALIAN ARTIFICIAL CHROMOSOMES - VECTORS FOR SOMATIC GENE-THERAPY, Cancer letters, 118(2), 1997, pp. 135-142
Citations number
62
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
118
Issue
2
Year of publication
1997
Pages
135 - 142
Database
ISI
SICI code
0304-3835(1997)118:2<135:MAC-VF>2.0.ZU;2-P
Abstract
Mammalian artificial chromosomes might prove to be useful vectors for somatic gene therapy. The functional elements of such an artificial ch romosome are telomeres, a centromere and a replication origin. Recent progress in the characterization of these functional elements of the e ukaryotic chromosome will be described. Attempts to construct artifici al chromosomes for mammalian cells and their use for somatic gene ther apy are discussed. (C) 1997 Elsevier Science Ireland Ltd.